Empty your bladder before going to bed. Store Nocdurna tablets in their original foil blister pack. Remove a tablet only when you are ready to take it.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems. While treating nighttime bed-wetting, avoid drinking anything within 1 hour before your bedtime dose of desmopressin. Do not drink anything until the next morning, or at least 8 hours after you have taken the medicine. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Tell your doctor about all your current medicines. Many drugs can affect desmopressin, especially:. This list is not complete and many other drugs may affect desmopressin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. This information does not replace the advice of a doctor. Treatment with the tablets for PNE should be interrupted during acute illnesses e. For all uses of desmopressin, particular attention should be paid to an extreme decrease in plasma osmolality. This is a rare occurrence, but can lead to seizures, possible coma, and death. In patients with diabetes insipidus or polyuria and polydipsia associated with head injury or surgery, urine volume and osmolality, and in some cases, plasma osmolality should be monitored periodically during therapy.
In patients treated for nocturnal enuresis, serum electrolytes should be checked if therapy is continued beyond 7 days. Patients with polydipsia should not receive desmopressin for the treatment of bleeding abnormalities due to its antidiuretic effects. Desmopressin should not be used in severe classic von Willebrand's disease type 1 disease , when there is evidence of an abnormal molecular form of factor VIII antigen, hemophilia B, or in patients with factor VIII antibodies.
Desmopressin may be active in some, but not all, cases of type 2A, 2M, or 2N von Willebrand's disease. Although desmopressin has been effective in patients with type 2B disease, it is not usually used in these patients because of an increased risk of thromboembolism.
Desmopressin is not active against type 3 von Willebrand's disease. Administration of intranasal desmopressin may be compromised by nasal mucosa changes e. Chronic desmopressin administration may result in changes to nasal mucosa scarring and edema , which may cause erratic and unreliable absorption.
Intravenous desmopressin should be considered when indicated. Although the manufacturer states that nasal congestion does not affect the absorption of intranasal desmopressin, some clinicians recommend a higher dose.
In patients receiving desmopressin nasal spray for nocturia, discontinue treatment in patients with concurrent nasal conditions that may increase systemic absorption of desmopressin e. Desmopressin nasal spray can be resumed when these conditions resolve. In general, most reported clinical experience with desmopressin has not identified efficacy response differences between geriatric and younger patients.
Geriatric patients 65 years of age and older treated with desmopressin for nocturia had a higher incidence of hyponatremia compared to patients less than 65 years old; therefore, monitor serum sodium more frequently in these patients. The risk of toxic reactions including water intoxication and low sodium concentrations appears to be greater in the geriatric patient and other patients with impaired renal function.
In general, dose selection for the geriatric patient should be cautious, usually starting at the low end of the dosing range. Baseline renal function should be assessed. Desmopressin is contraindicated in patients with moderate to severe renal impairment e. Monitor renal function and clinical status closely during use. According to the Beers Criteria, desmopressin is considered a potentially inappropriate medication PIM in geriatric adults and avoidance is recommended for treating nocturia or nocturnal polyuria because there is a high risk of hyponatremia and safer alternatives are available.
There are no adequate studies of the effects of desmopressin on the human fetus, but animal reproduction studies have shown no adverse fetal effects. The use of desmopressin for nocturia is not recommended in pregnant women; nocturia is usually related to normal, physiologic changes during pregnancy that do not require treatment with desmopressin. Although data regarding the use of desmopressin in the management of diabetes insipidus during pregnancy include a few reports of congenital anomalies and low birth weight babies, no causal connection between these events and desmopressin acetate has been established.
In a year study of desmopressin acetate in pregnant women with diabetes insipidus, the rate of birth defects was no greater than that in the general population; however, the statistical power of this study is low.
As opposed to preparations containing natural hormones, desmopressin acetate in antidiuretic doses has no uterotonic action. In addition, a systematic review of 30 studies pregnancies total of desmopressin for the treatment and prophylaxis of bleeding disorders in pregnancy concluded that in selected cases desmopressin is effective in reducing bleeding complications associated with pregnancy and childbirth with a good safety record; more research is needed since these were small studies.
The possible therapeutic advantages must be weighed against the possible risks in each case. Caution should be exercised when desmopressin is administered to a woman who is breast-feeding. Desmopressin is present in small amounts in human milk and is poorly absorbed by an infant. There is no information on the effects of desmopressin on the breast-fed infant or on milk production.
In a single study of postpartum women receiving a single dose of intranasal desmopressin, a marked change in plasma concentration of desmopressin was seen; however, little, if any, change in assayable desmopressin was found in breast milk. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition.
If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. There are literature data in mice which describe an effect of desmopressin and vasopressin on spermatazoa, leading to reduced sperm counts oligospermia and altered sperm motility, which may have implications for human male infertility. More study is needed. No effects on female fertility have been noted.
Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Acetaminophen; Chlorpheniramine; Phenylephrine : Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Acetaminophen; Dextromethorphan; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Acetaminophen; Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Amlodipine; Celecoxib: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. Use combination with caution, and monitor patients for signs and symptoms of hyponatremia.
A woman who took both desmopressin and ibuprofen was found in a comatose state. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Articaine; Epinephrine: Minor The antidiuretic response to desmopressin may be reduced in patients receiving high doses of epinephrine concomitantly. Caution should be used when coadministering these agents. Azelastine; Fluticasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Desmopressin can be started or resumed 3 days or 5 half-lives after the corticosteroid is discontinued, whichever is longer. Beclomethasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Betamethasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Brompheniramine; Carbetapentane; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Brompheniramine; Dextromethorphan; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Brompheniramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Budesonide: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Budesonide; Formoterol: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Budesonide; Glycopyrrolate; Formoterol: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Bumetanide: Major Desmopressin, when used in the treatment of nocturia is contraindicated with loop diuretics because of the risk of severe hyponatremia.
Bupivacaine; Meloxicam: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Carbamazepine: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with water intoxication, hyponatremia, or SIADH including carbamazepine.
The administration of carbamazepine prior to administration of desmopressin may act to reduce the duration of action of desmopressin. Carbetapentane; Chlorpheniramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Carbetapentane; Diphenhydramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Carbetapentane; Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Carbetapentane; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Carbetapentane; Phenylephrine; Pyrilamine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Carbinoxamine; Hydrocodone; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Carbinoxamine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Celecoxib: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Chlophedianol; Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Chlorpheniramine; Dextromethorphan; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Chlorpheniramine; Dihydrocodeine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Chlorpheniramine; Hydrocodone; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Chlorpheniramine; Ibuprofen; Pseudoephedrine: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Chlorpheniramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Chlorpromazine: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with water intoxication, hyponatremia, or SIADH including chlorpromazine. Chlorpropamide: Moderate Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with SIADH including chlorpropamide.
Use this combination with caution, and monitor patients for signs and symptoms of hyponatremia. Although rare, chlorpropamide has caused a reaction identical to symptom of inappropriate antidiuretic hormone SIADH. Ciclesonide: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Cisplatin: Moderate Frequently monitor serum sodium levels if concurrent use of desmopressin and cisplatin is necessary.
Cisplatin can cause hyponatremia, which may increase the risk of water intoxication in patients receiving treatment with desmopressin. Codeine; Phenylephrine; Promethazine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Corticosteroids: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Cortisone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Deflazacort: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Demeclocycline: Major The antidiuretic response to desmopressin or vasopressin ADH may be reduced in patients concomitantly receiving demeclocycline.
Dexamethasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Dextromethorphan; Diphenhydramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Dextromethorphan; Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Diclofenac: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Diclofenac; Misoprostol: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Diflunisal: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Diphenhydramine; Hydrocodone; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Diphenhydramine; Ibuprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Diphenhydramine; Naproxen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Diphenhydramine; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Dopamine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like dopamine only with careful patient monitoring. Epinephrine: Minor The antidiuretic response to desmopressin may be reduced in patients receiving high doses of epinephrine concomitantly. Ethacrynic Acid: Major Desmopressin, when used in the treatment of nocturia is contraindicated with loop diuretics because of the risk of severe hyponatremia.
Ethanol: Minor Acute alcohol intoxication causes diuresis presumably resulting from inhibition of vasopressin release from the posterior pituitary gland. Based on this response, the antidiuretic response to desmopressin may be reduced in patients receiving ethanol concomitantly. Minor Acute ethanol intoxication causes diuresis presumably resulting from inhibition of vasopressin release from the posterior pituitary gland.
Etodolac: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Famotidine; Ibuprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Fenoprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Fludrocortisone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Flunisolide: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Flurbiprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Fluticasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Fluticasone; Salmeterol: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Fluticasone; Umeclidinium; Vilanterol: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Fluticasone; Vilanterol: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Formoterol; Mometasone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia. Furosemide: Major Desmopressin, when used in the treatment of nocturia is contraindicated with loop diuretics because of the risk of severe hyponatremia. Guaifenesin; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Heparin: Minor Desmopressin has been shown to have an additive effect on the anticoagulant activity of heparin. Hydrocodone; Ibuprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Hydrocodone; Phenylephrine: Moderate Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring.
Hydrocortisone: Major Desmopressin, when used in the treatment of nocturia is contraindicated with corticosteroids because of the risk of severe hyponatremia.
Ibuprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Ibuprofen; Oxycodone: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Ibuprofen; Pseudoephedrine: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Indomethacin: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Ketoprofen: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Ketorolac: Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with hyponatremia including NSAIDs.
The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Lamotrigine: Major Caution is recommended if a drug that may increase the risk of water intoxication with hyponatremia, such as lamotrigine, is administered with desmopressin acetate. Two children with diabetes insipidus had decreasing desmopressin requirements with lamotrigine initiation. Cochrane Database Syst Rev. Eur J Pediatr. Epub Feb Hello, I'm 31 years old male.
I'm posting here because maybe i can find answers. Around a year ago, I suddenly while sitting infront of the pc started to feel pain in the left testicle. I remember Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions.
Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions. In this series. In this article What is desmopressin? How does desmopressin work? How effective is desmopressin?
What are the advantages of desmopressin? What are the disadvantages of desmopressin? When and how is desmopressin used? Are there any side-effects with desmopressin? Bedwetting Medicine Desmopressin In this article What is desmopressin? It works in about 7 in 10 cases. What is desmopressin? It comes in two tablet forms: A tablet which is swallowed. A melt tablet which is put under the tongue to dissolve and go straight into the bloodstream.
The advantage of the melt form is that it is not affected by food in the stomach. How to use the Yellow Card Scheme If you think you have had a side-effect to one of your medicines you can report this on the Yellow Card Scheme.
If you wish to report a side-effect, you will need to provide basic information about: The side-effect. The name of the medicine which you think caused it. The person who had the side-effect. Your contact details as the reporter of the side-effect. Previous article Bedwetting Alarms. Are you protected against flu? Further reading and references. The best solutions for bedwetting.
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